|
| |
Welcome to CyberCancer.info |
|
| |
| |
We're glad you're visiting our cancer treatment resource. At CyberCancer.info you will find great resources,
articles, links and more about cancer treatment.
We hope you enjoy our cancer treatment website, and we wish
you the best!
~ The CyberCancer.info Staff |
|
| |
| |
Here are some articles to start
with. |
|
| |
| |
|
|
| |
| |
Circulating igf-binding protein 7 (igfbp7) levels are elevated in patients with endometriosis or undergoing diabetic hemodialysis
Conclusion:
Our observations suggest that IGFBP7 is associated with the pathophysiology of endometriosis and diabetes mellitus, and that serum IGFBP7 levels do not reflect enhanced uterine expression of IGFBP7 mRNA during the menstrual cycle. (Source: Reproductive Biology and Endocrinology)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Neoplastic effects of exemestane in premenopausal breast cancer model.
Authors: Kubatka P, Sadlonova V, Kajo K, Machalekova K, Ostatnikova D, Nosalova G, Fetisovova Z
Aromatase inhibitor exemestane as a single - agent has no established role in the treatment of premenopausal breast cancer women. The aim of this study was to evaluate preventive effects of exemestane in the model of premenopausal Nmethyl- N-nitrosourea - induced mammary carcinogenesis in female rats. Exemestane treatment begun 7 days prior to carcinogen administration and continued next 12 weeks - till the end of experiment. Exemestane was dietary administered in two concentrations of 1 mg / 1kg (EXE 1), or 10 mg/1 kg (EXE 10), respectively. Exemestane increased the tumor frequency by 80.5 % (P=0.034) in the group EXE 1 and by 61.5 % (P=0.045) in the group EXE 10 in comparison with control ...
Lower uterine segment involvement is associated with adverse outcome in patients with stage i endometroid endometrial cancer: results of a multicenter study.
CONCLUSIONS: In patients with apparent stage I endometroid endometrial cancer, the presence of LUSI is a poor prognostic factor, associated with a significantly higher risk of distal recurrence and death. The presence of LUSI warrants consideration when deciding upon surgical staging or postoperative management.
PMID: 19013746 [PubMed - as supplied by publisher] (Source: European Journal of Surgical Oncology)
Researchers find no link between ivf and breast cancer
Fertility treatment does not increase a woman's risk of developing breast cancer, according to a study of more than 25,000 women in the Netherlands.The large study will help to reassure patients concerned that the powerful hormone doses that are part of fertility treatment might put them at risk of developing the disease in the future.At the beginning of an IVF treatment cycle, women are given hormone drugs to stimulate their ovaries to produce more eggs so that clinicians can produce fertilised embryos in vitro. These lead to large spikes in oestrogen levels that could promote the development of breast cancer, which is sensitive to the hormone. The study, carried out by Dr Alexandra van den Belt-Dusebout at the Netherlands Cancer Institute in Amsterdam, compared 18,970 women who had had a...
Allergies may prevent some cancers
There may be a silver -- and healthy -- lining to the miserable cloud of allergy symptoms: Sneezing, coughing, tearing and itching just may help prevent cancer -- particularly colon, skin, bladder, mouth, throat, uterus and cervix, lung and gastrointestinal tract cancer, according to a new Cornell study. (Source: Health News from Medical News Today)
The miseries of allergies just may help prevent some cancers
There may be a silver -- and healthy -- lining to the miserable cloud of allergy symptoms: Sneezing, coughing, tearing and itching just may help prevent cancer -- especially colon, skin, bladder, mouth, throat, uterus and cervix, lung and gastrointestinal tract cancer, as per a new Cornell study. These cancers, interestingly, involve organs that "interface directly with the external environment," said Paul Sherman, Cornell professor of neurobiology and behavior, who led the study. He and his colleagues analyzed 646 studies on allergies and cancers published over the past 50 years, putting together "the most comprehensive database yet available" on allergies and cancers........ (Source: Medicineworld.org: New Article Alert)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
The miseries of allergies just may help prevent some cancers, study finds
(Cornell University Communications) There may be a silver -- and healthy -- lining to the miserable cloud of allergy symptoms: Sneezing, coughing, tearing and itching just may help prevent cancer -- particularly colon, skin, bladder, mouth, throat, uterus and cervix, lung and gastrointestinal tract cancer, according to a new Cornell study. (Source: EurekAlert! - Cancer)
Dkk3, downregulated in cervical cancer, functions as a negative regulator of [beta]-catenin
The Wnt/[beta]-catenin signaling pathway is activated during the malignant transformation of keratinocytes that originate from the human uterine cervix. Dkk1, 2 and 4 have been shown to modulate the Wnt-induced stabilization of the [beta]-catenin signaling pathway. However, the function of Dkk3 in this pathway is unknown. Comparison of the Dkk3 gene expression profiles in cervical cancer and normal cervical tissue by cDNA microarray and subsequent real-time PCR revealed that the Dkk3 gene is frequently downregulated in the cancer. Methylation studies showed that the promoter of Dkk3 was methylated in cervical cancer cell lines and 22 (31.4%) of 70 cervical cancer tissue specimens. This promoter methylation was associated with reduced expression of Dkk3 mRNA in the paired normal and tumor t...
Multiple painful cutaneous facial papules.
This report describes a patient with cutaneous piloleiomyoma and discusses important associations including uterine leiomyomas, leiomyosarcomas, and renal cell carcinoma. Differential diagnoses and other familial renal cancer syndromes are succinctly reviewed.Page: 1180DOI: 10.1097/SMJ.0b013e31817ecbbbAuthors: Hernandez, Claudia MD; Rivera, Carmen M. BA (Source: Southern Medical Journal)
Spirs: a web-based image retrieval system for large biomedical databases.
CONCLUSIONS: SPIRS is automated, easily accessible, and integratable with other complementary information retrieval systems. The system supports the ability for users to intuitively query large amounts of imaging data by providing visual examples and text keywords and has beneficial implications in the areas of research, education, and patient care.
PMID: 18996737 [PubMed - as supplied by publisher] (Source: International Journal of Medical Informatics)
Overexpression of hmga2 in uterine leiomyomas points to its general role for the pathogenesis of the disease
An overexpression of HMGA2 is supposed to be a key event in the genesis of leiomyoma with chromosomal rearrangements affecting the region 12q14-15 targeting the HMGA2 gene, but gene expression data regarding differences between uterine leiomyomas with and those without 12q14-15 aberrations are insufficient. To address the question whether HMGA2 is only upregulated in the 12q14-15 subgroup, the expression of HMGA2 was analyzed in a comprehensive set of leiomyomas (n = 180) including tumors with 12q14-15 chromosomal aberrations (n = 13) and matching myometrial tissues (n = 51) by quantitative RT-PCR. The highest expression levels for HMGA2 were observed in tumors with rearrangements affecting the region 12q14-15, but although HMGA2 is expressed at lower levels in leiomyomas without such aber...<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
The cytosol activity of thymidine phosphorylase in endometrial cancer
Conclusions:
The cytosol TP activity in endometrial cancer is significantly higher than in normal endometrium, with no relation as to the stage and grade of tumors, but correlates with the PD-ECGF/TP protein expression and MD may therefore be associated with favorable prognosis in patients treated with chemo- or radiotherapy after surgery. (Source: BMC Medical Genomics)
The relationship between pdgf and angiogenesis in endometrial cancer
Conclusion There was positive correlation between microvessel density (MVD) and PDGF in earlier stage of EC, it illustrate that PDGF
may take part in angiogenesis of EC.
Content Type Journal ArticleDOI 10.1007/s10330-008-0104-1Authors
Shuang Chen, Maternal and Child Health Hospital of Jinzhou Department of Gynaecology and Obstetrics Jinzhou 121000 ChinaCaigang Liu, The First Affiliated Hospital of China Medical University Department of Oncology Shenyang 110001 ChinaYonglai Wang, Shengjing Hospital of China Medical University Department of Gynaecology and Obstetrics Shenyang 110004 ChinaSong Gao, Shengjing Hospital of China Medical University Department of Gynaecology and Obstetrics Shenyang 110004 China
Journal The Chinese-German Journal of Clinical OncologyOnli...
In silico
analysis of protein neoplastic biomarkers for cervix and uterine cancer
Abstract Worldwide, cervical and uterine cancers are the most deadly cancers in women, with high prevalences, especially in developing
countries. The Human Protein Atlas (HPA) portal was explored for proteins expressed in a tissue-or cervix and uterine cancer-specific
manner. The group of proteins differentially expressed and with enhanced expression in the glandular and surface epithelial
(squamous) cells retrieved from HPA were further explored using the Protein Information and Knowledge Extractor (PIKE) portal
to compile biological information that is found in different databases, and repositories on the Internet. Thus, the lists
of candidate proteins found in HPA, and PIKE portals may be used as a starting point for the discovery and validation of biomarkers
for cervix...
Prevalence of high-risk human papillomavirus among older women.
CONCLUSION: In this nationally representative population, nearly 1 in 16 women aged 57-85 was found to have high-risk HPV, and prevalence was stable across older age groups. LEVEL OF EVIDENCE: II.
PMID: 18978096 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)
Sentinel lymph node sampling in gynaecological cancers: techniques and clinical applications.
CONCLUSIONS: The SLN procedure appears to reliably predict the metastatic status of the regional lymphatic basin in patients with vulval and cervical cancers. More work is needed to establish the role of SLN sampling in endometrial and ovarian cancers.
PMID: 18980825 [PubMed - as supplied by publisher] (Source: European Journal of Surgical Oncology)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Progression of conservatively treated endometrial complex atypical hyperplasia in a young woman: a case report
Conclusion(s): Conservative therapy is feasible in carefully selected young women with endometrial CAH. However, close follow-up is required because of possible progression to endometrial cancer. (Source: Fertility and Sterility)
Does the fimbria have an embryologic origin distinct from that of the rest of the fallopian tube?
Conclusion(s): The two cases of pure congenital fallopian tube atresia, the presence of fimbriae in patients with müllerian (uterine, cervical, and vaginal) agenesis, and the role of the fimbria in ovarian-like and peritoneal cancers, support a novel hypothesis that the fimbria of the fallopian tube may arise separately from the rest of the tube. (Source: Fertility and Sterility)
A microrna encoded in a highly conserved part of the mammalian hmga2 gene.
A microRNA encoded in a highly conserved part of the mammalian HMGA2 gene.
Cancer Genet Cytogenet. 2008 Nov;187(1):43-4
Authors: von Ahsen I, Nimzyk R, Klemke M, Bullerdiek J
The high mobility group protein HMGA2 plays an important role as a chromatin component of stem cells and as a protein causally related to the development of a variety of benign tumors (e.g., uterine leiomyomas, lipomas, and pleomorphic adenomas of the salivary glands). Herein, the existence of a highly conserved region within intron 3 of HMGA2 encoding a microRNA is described. The co-expression with HMGA2 suggests that as an intronic microRNA, this microRNA may cooperate with HMGA2 in its physiological and/or aberrant functions.
PMID: 18992641 [PubMed - in process] (Source: Cancer Genetics and Cytogene...
[digital cervicography criteria: improving sensitivity in uterine cervical cancer diagnosis.]
This study aimed to validate the scoring criteria for digital cervicography. The study enrolled 300 women submitted to a clinical protocol using cytological examination alone, digital cervicography without image magnification (Evaluation 1), and digital cervicography plus additional image magnification and considering the positive criteria (Evaluation 2). Women's mean age was 27.6 years. Positive criteria for digital cervicography were identified in 111 positive cases with pre-cancerous cervical lesions (100%) and in 8 cases classified as false positives (2.6%). Evaluations 1 and 2 classified the tests as positive (163; 54.3%) and suspected (146; 48.6%), respectively. According to the findings, digital cervicography was more sensitive (99.1%) and cytology more specific (100%). Digital cerv...
[coverage of pap smear tests in the city of são leopoldo, rio grande do sul state, brazil.]
[Coverage of Pap smear tests in the city of São Leopoldo, Rio Grande do Sul State, Brazil.]
Cad Saude Publica. 2008 Nov;24(11):2511-20
Authors: Muller DK, Dias-da-Costa JS, Luz AM, Olinto MT
This cross-sectional study aimed to verify the coverage of Pap smear tests and associated factors in a cluster sample of women 20 to 60 years of age in the city of São Leopoldo, Rio Grande Sul State, Brazil, in 2003. Two outcomes were analyzed: Pap smear in the previous three years and Pap smear never performed. Among 867 women, 741 (85.5%; 95%CI: 83.1-87.8) had a Pap smear in the previous three years, 60 (6.9%; 95%CI: 5.2-8.6) were late with the test, and 66 (7.6%; 95%CI: 5.8-9.4) had never done a Pap smear. Poisson regression showed significant association with: income, age, ski...<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Dietary genistein negates the inhibitory effect of letrozole on the growth of aromatase-expressing estrogen-dependent human breast cancer cells (mcf-7ca) in vivo
In conclusion, dietary GEN increased the growth of MCF-7Ca tumors implanted in ovariectomized mice and could also negate the inhibitory effect of LET on MCF-7Ca tumor growth. These findings are significant because tumors, which express aromatase and synthesize estrogen, are good candidates for aromatase therapy dietary and GEN can reverse the inhibitory effect of LET on tumor growth and adversely impact breast cancer therapy. Caution is warranted for consumption of dietary GEN by postmenopausal women with estrogen-dependent breast cancer taking LET treatment. (Source: Carcinogenesis)
A feasibility study of topotecan with standard-dose cisplatin and concurrent primary radiation therapy in locally advanced cervical cancer.
CONCLUSIONS: The addition of weekly topotecan to cisplatin at this dose and schedule during pelvic irradiation for locally advanced cervical cancer appears to be feasible. Based on this primary treatment data and the activity of cisplatin-topotecan in the recurrent disease setting, phase II and III studies of this combination are warranted.
PMID: 18977518 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Cyclooxygenase-2 expression in squamous cell carcinoma of the uterine cervix is associated with lymph node metastasis.
CONCLUSIONS: In this study, COX-2 expression was associated with lymph node metastasis in cervical squamous cell carcinoma, but this was linked to the presence of LVSI or parametrial involvement. This suggests that COX-2 expression may enhance lymph node metastasis after LVSI occurs. If so, immunohistochemical staining for COX-2 may provide additional prognostic information in LVSI-positive cases, in particular in patients who do not receive postoperative adjuvant treatment.
PMID: 18977022 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Pitfalls in immunohistochemical validation of tumor marker expression - exemplified in invasive cancer of the uterine cervix.
CONCLUSIONS: Failure to analyse clinical stages separately, failure to adjust for expression of relevant concurrent tumor markers and inclusion of different histological subtypes into the same study group may lead to false conclusions regarding the significance of prognostic tumor markers.
PMID: 18976801 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Sex hormone binding globulin and aging
Horm Metab ResDOI: 10.1055/s-0028-1093351AbstractNew and more active concepts of steroid binding globulin action are emerging from recent research. As a result, examination of steroid levels in aging humans and the role of steroid binding globulins need to be re-visited. This review will discuss the possibility that sex hormone binding globulin (SHBG) plays an active role in the aging process. It will discuss the changes in blood levels of SHBG in aging humans in association with sexual activity, prostate hypertrophy and cancer, uterine leiomyoma, breast cancer, obesity and particularly the relationship between SHBG and HDL-cholesterol, Alzheimer's disease, osteoporosis, and cardiovascular disease. Starting with the idea that SHBG is an active participant in steroid action demands a re-eva...<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Complex organisation and structure of the ghrelin antisense strand gene ghrlos, a candidate non-coding rna gene
Conclusion:
GHRLOS RNA transcripts display several distinctive features of non-coding (ncRNA) genes, including 5' capping, polyadenylation, extensive splicing and short open reading frames. The gene is also non-conserved, with differential and tissue-restricted expression. The overlapping genomic arrangement of GHRLOS with the ghrelin gene indicates that it is likely to have interesting regulatory and functional roles in the ghrelin axis. (Source: BioMed Central)
Expression of the inhibitor of dna-binding (id)-1 protein as an angiogenic mediator in tumour advancement of uterine cervical cancers
Expression of the inhibitor of DNA-binding (ID)-1 protein as an angiogenic mediator in tumour advancement of uterine cervical cancers
British Journal of Cancer advance online publication, October 28, 2008. doi:10.1038/sj.bjc.6604722
Authors: M K Maw, J Fujimoto
& T Tamaya (Source: British Journal of Cancer AOP)
Microrna signature and regulatory functions in the endometrium during normal and disease states
Semin Reprod Med 2008; 26: 479-493DOI: 10.1055/s-0028-1096128ABSTRACTDuring the menstrual cycle, human endometrium undergoes extensive cyclic morphologic and biochemical modifications in preparation for embryo implantation. These processes are highly regulated by ovarian steroids and various locally expressed gene products and involve inflammatory reaction, apoptosis, cell proliferation, angiogenesis, differentiation (tissue formation), and tissue remodeling. MicroRNAs (miRNAs) have emerged as key regulators of gene expression, and their altered and/or aberrant expression has been associated with establishment and progression of various disorders, including tumorigenesis. This review highlights the endometrial expression of miRNAs and their potential regulatory functions under normal and p...
Patterns of care and outcome in elderly cervical cancer patients: a special focus on brachytherapy.
CONCLUSIONS: Elderly women with cervical cancer tolerated BT well and had excellent local disease-free and specific survival rates. Age did not influence the effectiveness of BT in elderly patients and BT should be considered whenever possible, even in elderly patients presenting with a cervix cancer.
PMID: 18954913 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Prevalence of high-risk human papillomavirus type 16/18 infection among women with normal cytology: risk factor analysis and implications for screening and prophylaxis
Conclusions: Although the sample size was small, based on the observation that HR-HPV 16 and 18 contributed significantly to the overall HPV prevalence in our setting, we speculate that testing/prophylaxis for these prevalent high-risk types could perhaps make cervical cancer screening and preventive programmes cost-effective. Larger community-based studies on HPV prevalence and persistence are required to validate these findings before definitive recommendations can be made to the policy makers. (Source: Cytopathology)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Novel therapeutic strategy for uterine endometrial cancers
Abstract In general, tumors induce angiogenic factors specific to them, which leads to angiogenesis with tumor progression. However,
angiogenesis in uterine endometrial cancers is complicated because the hormone dependency in their growth also modifies the
angiogenic potential. Therefore, angiogenic potential in uterine endometrial cancers must be thoroughly analyzed. The upstream
of the vascular endothelial growth factor (VEGF) gene conserves estrogen-responsive elements. Progesterone primed with estrogen induces thymidine phosphorylase (TP) in the
uterine endometrium. Sex steroid-dependent VEGF and TP are highly expressed in early-stage and well-differentiated uterine
endometrial cancers, and basic fibroblast growth factor (bFGF) is highly expressed in advanced and poorly...
Is electron beam intraoperative radiotherapy (eliot) safe in pregnant women with early breast cancer? in vivo dosimetry to assess fetal dose
Abstract Electron beam intraoperative radiotherapy (ELIOT) is a new technique permitting breast radiotherapy to be completed in a single
session. Since ELIOT is associated with much reduced irradiation to nontarget tissues, we carried out a study on nonpregnant
breast cancer patients to estimate doses to the uterus during ELIOT to better evaluate the possible use of ELIOT in pregnant
breast cancer patients. We performed in vivo dosimetry with thermoluminescence radiation detectors (TLDs) in 15 premenopausal
patients receiving ELIOT to the breast (prescribed dose 21 Gy) using two mobile linear accelerators. The TLDs were positioned
subdiaphragmatically on the irradiated side, at the medial pubic position, and within the uterus. A shielding apron (2 mm
lead eq...
Birth control has long-term effect on hormone exposure
Researchers at Wake Forest University School of Medicine may be one step closer to understanding why past oral contraceptive use dramatically lowers the risk of ovarian and uterine cancers later in life. (Source: Huliq Health News)
Birth control has long term effect on hormone exposure
Researchers at Wake Forest University School of Medicine may be one step closer to understanding why past oral contraceptive use dramatically lowers the risk of ovarian and uterine cancers later in life. While studying the effect of post-menopausal dietary soy consumption on estrogen metabolism in cynomolgus monkeys, Latanya M. Scott, Ph.D., discovered that monkeys who had been given birth control earlier in life had a reduced amount of estrogen excreted in their urine. (Source: Cancer / Oncology News From Medical News Today)
Birth control has long-term effect on hormone exposure
(Wake Forest University Baptist Medical Center) Researchers at Wake Forest University School of Medicine may be one step closer to understanding why past oral contraceptive use dramatically lowers the risk of ovarian and uterine cancers later in life. (Source: EurekAlert! - Cancer)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Role of protease activated receptor-2 in lymph node metastasis of uterine cervical cancers
Background:
Protease activated receptor-2 (PAR-2) has been implicated in cellular proliferation, invasion and metastasis in various tumors. Lymph node metastasis is an important patient prognostic factor for uterine cervical cancers. This prompted us to study the role of PAR-2 in lymph node metastasis of uterine cervical cancers.
Methods:
Thirty patients underwent surgery for uterine cervical cancers. PAR-2 histoscores and mRNA levels were determined by immunohistochemistry and real-time reverse transcription-polymerase chain reaction, respectively. Patient prognosis was analyzed with a 48-month survival rate.
Results:
PAR-2 histoscores and mRNA levels significantly (P (Source: BMC Cancer)
Performance of integrated fdg-pet/contrast-enhanced ct in the diagnosis of recurrent uterine cancer: comparison with pet and enhanced ct
Conclusion FDG-PET/contrast-enhanced CT is a more accurate modality for assessing recurrence of uterine cancer, and led to more appropriate
subsequent clinical management than that resulting from PET alone or enhanced CT alone.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00259-008-0956-1Authors
Kazuhiro Kitajima, Dokkyo University School of Medicine Department of Radiology Mibu JapanKoji Murakami, Dokkyo Medical University Hospital PET Center Mibu JapanErena Yamasaki, Dokkyo Medical University Hospital PET Center Mibu JapanYasushi Domeki, Dokkyo Medical University Hospital PET Center Mibu JapanYasushi Kaji, Dokkyo University School of Medicine Department of Radiology Mibu JapanSatoru Morita, Tokyo Women?s Medical University Medical Center East D...
Prospective evaluation of prognostic significance of the tumor-free distance from uterine serosa in surgically staged endometrial adenocarcinoma.
CONCLUSIONS: TFD, like DOI, is predictive of many surgicopathological variables and patient outcome in surgically staged endometrial cancer. Although the performance characteristics may not be as powerful as DOI, the ease and reproducibility of this measurement may justify its inclusion in synoptic reporting of endometrial cancer.
PMID: 18937970 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Relationship between tamoxifen use and high risk endometrial cancer histologic types.
CONCLUSIONS: Among women with endometrial carcinoma, those with a history of breast cancer are more likely to harbor a high risk uterine histologic subtype. Tamoxifen use of at least 60 months is associated with high risk uterine histologic subtypes when compared to no tamoxifen use. This study adds to existing data suggesting a relationship between tamoxifen use and development of endometrial carcinoma of more aggressive histologic types.
PMID: 18937966 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Positron emission tomography with the glucose analog [18f]-fluoro-2-deoxy-d-glucose for evaluating pelvic lymph node metastasis in uterine corpus cancer: comparison with ct and mri findings
Conclusions: We suggest that current imaging modalities including FDG-PET cannot change medical management of patients with uterine corpus cancer before surgery. (Source: Journal of Obstetrics and Gynaecology Research)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
Characterization of anti-estrogenic activity of the chinese herb, prunella vulgaris, using in vitro and in vivo (mouse xenograft) models.
Characterization of Anti-Estrogenic Activity of the Chinese Herb, Prunella vulgaris, Using In Vitro and In Vivo (Mouse Xenograft) Models.
Biol Reprod. 2008 Oct 15;
Authors: Collins NH, Lessey EC, Dusell CD, McDonnell DP, Fowler L, Palomino WA, Illera MJ, Yu X, Mo B, Houwing A, Lessey BA
Prunella vulgaris (PV), a commonly used Chinese herb, also known as Self-heal, has a wide range of reported medicinal activities. By screening multiple herbs using the endometrial cancer cell line ECC-1 and an alkaline phosphatase detection assay, we found PV displayed significant anti-estrogenic activity. We investigated the possible usefulness of anti-estrogenic activity using both in vitro and in vivo models of endometrial function. Using the well-differentiated hormone responsive endometrial...
The rate of port-site metastases after 2251 laparoscopic procedures in women with underlying malignant disease.
CONCLUSION: The rate of port-site tumor implantation after laparoscopic procedures in women with malignant disease is low and almost always occurs in the setting of synchronous, advanced intraabdominal or distant metastatic disease. The presence of port-site implantation is a surrogate for advanced disease and should not be used as an argument against laparoscopic surgery in gynecologic malignancies.
PMID: 18929404 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Wilms' tumor gene 1 (wt1) in endometrial carcinoma.
CONCLUSION: Although WT1 is expressed in a majority of endometrial carcinomas, a heterogeneous staining pattern is observed. This information is important for WT1-directed immunotherapy.
PMID: 18929401 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Mutagenicity of tamoxifen dna adducts in human endometrial cells and in silico prediction of p53 mutation hotspots
Tamoxifen elevates the risk of endometrial tumours in women and -(N2-deoxyguanosinyl)-tamoxifen adducts are reportedly present in endometrial tissue of patients undergoing therapy. Given the widespread use of tamoxifen there is considerable interest in elucidating the mechanisms underlying treatment-associated cancer. Using a combined experimental and multivariate statistical approach we have examined the mutagenicity and potential consequences of adduct formation by reactive intermediates in target uterine cells. pSP189 plasmid containing the supF gene was incubated with -acetoxytamoxifen or 4-hydroxytamoxifen quinone methide (4-OHtamQM) to generate dG-N2-tamoxifen and dG-N2-4-hydroxytamoxifen, respectively. Plasmids were replicated in Ishikawa cells then screened in Escherichia coli. Tre...
Vitamin d a key player in overall health of several body organs, says uc riverside biochemist
(University of California - Riverside) Vitamin D, once linked to only bone diseases, is now recognized as a major player in contributing to overall human health, emphasizes UC Riverside's Anthony Norman, an international expert on vitamin D. He lists 36 organ tissues in the body whose cells respond biologically to vitamin D. The list includes bone marrow, breast, colon, intestine, kidney, lung, prostate, retina, skin, stomach and the uterus. According to Norman, vitamin D deficiency can impact all 36 organs. (Source: EurekAlert! - Cancer)<p> </p><p><b><i>MedWorm Sponsored Message:</i></b> Find out how you can <a href="http://www.medworm.com/rss/medicalsponsorship.php" target="_self">get your message across here</a> by sponsoring this MedWorm news feed.</p>
A joinpoint regression analysis of long-term trends in cancer mortality in japan (1958-2004)
Cancer is one of the major targets of disease control programs in Japan. A Joinpoint regression model was used to analyze the long-term trends of mortality related to overall cancer and the 15 most common cancers based on published data from the National Vital Statistics of Japan between 1958 and 2004. Since 1996, a decline has been seen in overall cancer for both sexes in Japan. Most of the common sites, including cancers of the stomach, colon, liver, gallbladder and lung and leukemia in both sexes, cancer of esophagus in men and rectal and ovarian cancers in women showed a decreasing trend, and cancers of the rectum, pancreas, prostate and urinary bladder and malignant lymphoma in men and cancers of the esophagus and uterus in women leveled off during the most recent period. However, an ...
N-acetylglucosaminyltransferase v regulates extravillous trophoblast invasion through glycosylation of {alpha}5{beta}1 integrin.
N-acetylglucosaminyltransferase V Regulates Extravillous Trophoblast Invasion through Glycosylation of {alpha}5{beta}1 integrin.
Endocrinology. 2008 Oct 9;
Authors: Yamamoto E, Ino K, Miyoshi E, Inamori KI, Abe A, Sumigama S, Iwase A, Kajiyama H, Shibata K, Nawa A, Kikkawa F
For successful human placentation, invasion of trophoblast cells into the uterus and its associated vasculature is essential and the regulation of this process is controlled by many factors at the fetal-maternal interface. N-acetylglucosaminyltransferase V (GnT-V) is a key enzyme that catalyzes beta1, 6-N-acetylglucosamine (beta1-6GlcNAc) branching on asparagine-linked oligosaccharides of cell proteins. GnT-V and its product, beta1-6GlcNAc, are known to regulate cellular transformation and correlate with th...
Role of diffusion-weighted imaging in the diagnosis of gynecological diseases
Abstract Recent technical advances in diffusion-weighted imaging (DWI) greatly enhanced the clinical value of magnetic resonance imaging
(MRI) of the body. DWI can provide excellent tissue contrast based on molecular diffusion and may be able to demonstrate malignant
tumors. Quantitative measurement of the apparent diffusion coefficient (ADC) may be valuable in distinguishing between malignant
and benign lesions. We reviewed DWI and conventional MRI of the female pelvis to study the utility of DWI in patients with
gynecological diseases. Although the ADC can help to differentiate between normal and cancerous tissue in the uterine cervix
and endometrium, its utility may be limited by the large overlap of the uterine myometrium and ovaries. On the other hand,
the ADC may be ...
Cell-cycle and suppressor proteins expression in uterine cervix in hiv/hpv co-infection: comparative study by tissue micro-array (tma)
Background:
The oncoproteins of human papillomavirus (HPVs) directly effect cell-cycle control. We hypothesize that regulatory and cell cycle protein expression might be additionally modified in the cervix of HIV/HPV co-infected women.
Methods:
We analyzed the expression of Rb, p27, VEGF and Elf-1 transcriptor factor by immunohistochemistry in 163 paraffin-embeded cervical samples using Tissue Micro-Array (TMA) and correlated this to HIV-1 and HPV infection.
Results:
HIV/HPV co-infection was associated with a significant increase in expression (p (Source: BMC Cancer)
|
|
| |
|
|
|
|
